Used for
| Amount | Why |
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Chronic Venous Insufficiency | 500 mg hydroxyethylrutosides twice per day
| [3 stars] Flavonoids strengthen capillaries. A flavonoid derived from rutin, called HR, has been shown to be effective in clearing leg swelling and reducing other CVI symptoms. |
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Hepatitis | 500 to 750 mg daily of catechins | [3 stars] The flavonoid catechin has helped people with acute viral hepatitis, as well as people with chronic hepatitis. |
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Bruising | 400 to 800 mg hesperidin with vitamin C daily
| [2 stars] Flavonoids are often recommended with vitamin C. Flavonoids are vitamin-like substances that can help strengthen capillaries and therefore may also help with bruising. |
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Cold Sores (Vitamin C) | 200 mg with 200 mg flavonoids, three to five times daily | [2 stars] Vitamin C plus flavonoids may help speed cold sore healing.
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Dysmenorrhea | 200 mg niacin daily, 300 mg vitamin C daily, and 60 mg rutin daily througout menstrual cycle; for cramps: 100 mg niacin every two to three hours | [2 stars] Supplementing with a combination of vitamin B3, vitamin C, and the flavonoid rutin resulted in a 90% effectiveness for relieving menstrual cramps in one study. |
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Gingivitis (Vitamin C) | 300 mg of vitamin C, plus 300 mg of flavonoids daily | [2 stars] In one study, supplementing with vitamin C plus flavonoids improved gum health in a group of people with gingivitis. |
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Glaucoma | Refer to label instructions
| [2 stars] In one study, supplementation with anthocyanins (a type of flavonoid) significantly decreased the amount of visual field loss in patients with open-angle glaucoma. |
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Hemorrhoids | 600 to 4,000 mg hydroxyethylrutosides daily or 1 to 3 grams of a mixture of 90% diosmin and 10% hesperidin | [2 stars] Supplementing with flavonoids may reduce symptoms. A number of flavonoids have been shown to have anti-inflammatory effects and to strengthen blood vessels |
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Hypertension | 300–600 mg per day of hesperidin | [2 stars] Hesperidin, a flavonoid found primarily in oranges and other citrus fruits, has been found to decrease high blood pressure. |
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Ménière’s Disease | Refer to label instructions
| [2 stars] Certain flavonoids, known as hydroxyethylrutosides, have been reported to improve symptoms of Ménière’s disease, including hearing problems. |
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Skin Ulcers | 900 mg per day of diosmin and 100 mg per day of hesperidin | [2 stars] One trial found that a combination of the flavonoids diosmin and hesperidin promoted healing of venous leg ulcers. Hydroxyethylrutosides (related flavonoids) may also help. |
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Allergies and Sensitivities | Refer to label instructions
| [1 star] Test tube and animal studies have found some effects from natural antihistamines such as flavonoids, though no clinical research has shown whether these substances can specifically reduce allergic reactions.
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Capillary Fragility | Refer to label instructions
| [1 star] Flavonoids may help strengthen weakened capillaries, possibly by protecting collagen, one of the most important components of capillary walls. |
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Gingivitis | Refer to label instructions
| [1 star] Shown to be effective against gingivitis when taken with vitamin C, flavonoids also appear to be effective by themselves at reducing gum inflammation. |
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Glaucoma | Refer to label instructions
| [1 star] The flavonoid rutin may increase the effectiveness of conventional medication in people with glaucoma. |
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Measles | Refer to label instructions
| [1 star] Flavonoids are nutrients found in the white, pithy parts of fruits and vegetables. Certain flavonoids have been found to inhibit the infectivity of measles virus in the test tube. |
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Menopause | Refer to label instructions
| [1 star] A preliminary trial reported that a combination of vitamin C and the flavonoid hesperidin helped relieve hot flashes in menopausal women. |
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Menorrhagia | Refer to label instructions
| [1 star] Flavonoids protect capillaries (small blood vessels) from damage. In so doing, they might protect against the blood loss of menorrhagia. |
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Retinopathy | Refer to label instructions
| [1 star] Quercetin has been shown to inhibit aldose reductase, an enzyme that appears to contribute worsen diabetic retinopathy. Another flavonoid, rutin, may also improve retinopathy. |
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Varicose Veins | Refer to label instructions
| [1 star] Taking hydroxyethylrutoside may help reduce the size of varicose veins associated with pregnancy. |
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